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Lina Medawar

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Lina Medawar

After graduating from the dental school, Dr. Lina earned her Master degree in orthodontics and her Doctorate degree in Biomedical Engineering and Biomaterials. In addition, she earned her PhD degree in Orthodontics and Maxillofacial Orthopedics. She is a research associate at the Institute of Health and Medical Research (INSERM) as well.

Can Orthodontic Treatment Be A Carcinogenic Risk Factor?

Nickel alloys are often used in orthodontics. Ni is a corrosive material of which toxicity, allergenicity and carcinogenicity are recognized.
The aim of our research is to determine the susceptibility to the corrosion of NiTi alloy and its eventual influence to produce unwanted biological effects due to its high content of Ni. Moreover, it also aims to determine the influence of Nickel concentrations in saliva and its effects on human palatal cells (HEPM:Human Embryonic Palatal Mesenchyme).
The results confirm that Ni is highly corrosive and toxic causing damage to our target cell (HEPM), an inflammatory reaction with Multinucleated Giant Cells.
NiTi is more resistant to the corrosion due to the formation of a protected film TiO2. Nevertheless, any aggression applied on the material will break this film, make the material prone to corrosion and provoke Nickel release.

Learning objectives:
In order to maintain the ultimate health for patients, some guidelines were set to advice orthodontists how to:

  • Reduce nickel intake
  • Prevent or minimize the corrosion and the release of material degradation products from bands, brackets and /or wires into the oral environment
  • Better use their chosen materials